Lipid nanoparticles (LN) have gained immense attention these days as they avail the combined benefits of both lipids and nano sized particles. LN’s are considered to be a safer alternative to polymeric nanoparticles owing to their biodegradable and biocompatible nature. Thus the Lipid nanoparticles are preferred for oral administration of drugs with poor solubility and low bioavailability. The present work gives a detailed description of the nanostructured lipid carriers (NLC), their characteristics and types, mechanism of oral absorption and advantages. The various methods used for the preparation of NLC are briefly described. It also includes their characterization by means of particle size and zeta potential measurement, determination of entrapment efficiency, TEM analysis, DSC and XRD study, in-vitro – ex-vivo studies and stability study. Lyophilization process is also described as a means of stability enhancement and the characterization of lyophilized product is also included.
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